MedPath

Head to Head Study Against Sevelamer Hydrochloride

Phase 3
Completed
Conditions
Chronic Kidney Disease, Stage 5
Interventions
Registration Number
NCT00441545
Lead Sponsor
Shire
Brief Summary

To compare the efficacy of Fosrenol (Lanthanum carbonate) and sevelamer hydrochloride in the reduction of serum phosphorus levels from baseline.

Detailed Description

To compare the efficacy of Fosrenol (Lanthanum carbonate) and sevelamer hydrochloride in the reduction of serum phosphorus levels from baseline.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
182
Inclusion Criteria
  • Adults with end stage renal disease who are receiving dialysis
Exclusion Criteria
  • Subjects with significant gastrointestinal disorders
  • Subjects who are pregnant or nursing
  • Subjects currently taking lanthanum carbonate, sevelamer hydrochloride, cinacalcet hydrochloride
  • Subjects who are HIV positive
  • Subjects with clinical significant liver disease

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
1Fosrenol (Lanthanum Carbonate)Fosrenol (Lanthanum carbonate)
2Sevelamer hydrochlorideSevelamer hydrochloride
Primary Outcome Measures
NameTimeMethod
Change From Baseline in Serum Phosphorus Levels at 4 Weeks4 weeks
Secondary Outcome Measures
NameTimeMethod
Change From Baseline in Serum Calcium Levels at 4 Weeks4 weeks
Levels of Intact Parathyroid Hormone (iPTH) at Baseline and 4 WeeksBaseline and 4 weeks
Patients Achieving Kidney Disease Outcomes Quality Initiative (KDOQI) Target for Serum Phosphorous at 4 Weeks4 weeks

Kidney Disease Outcomes Quality Initiative (KDOQI) target for serum phosphorous is 3.5 - 5.5 mg/dL (1.13 - 1.77 mmol/L)

Trial Locations

Locations (43)

Apex Research of Riverside

🇺🇸

Riverside, California, United States

VA Greater Los Angeles Health Care System, West LA

🇺🇸

Los Angeles, California, United States

Rosa Verde Tower

🇺🇸

San Antonio, Texas, United States

University of Texas Health Science Center at San Antonio Medicine/Nephrology

🇺🇸

San Antonio, Texas, United States

VA Tennessee Valley Healthcare System

🇺🇸

Nashville, Tennessee, United States

Clinical Research Connections

🇺🇸

Jonesboro, Arkansas, United States

Jose Cangiano, MD

🇵🇷

San Juan, Puerto Rico

Renal Associates of Baton Rouge

🇺🇸

Baton Rouge, Louisiana, United States

Hypertension and Nephrology, Associates

🇺🇸

Eatontown, New Jersey, United States

DSI Renal Inc.

🇺🇸

Mesa, Arizona, United States

Southwest Kidney Institute, PLC

🇺🇸

Tempe, Arizona, United States

University of Arizona Health Service Center

🇺🇸

Tucson, Arizona, United States

South Valley Dialysis Center

🇺🇸

Encino, California, United States

Western Nephrology & Metabolic Bone Disease, PC

🇺🇸

Thornton, Colorado, United States

Discovery Medical Research Group

🇺🇸

Ocala, Florida, United States

North Valley Nephrology

🇺🇸

Yuba City, California, United States

Clinical Research Center of Indian River Medical Center

🇺🇸

Vero Beach, Florida, United States

Kidney Care Associates, LLC

🇺🇸

Augusta, Georgia, United States

Pines Clinical Research

🇺🇸

Pembroke Pines, Florida, United States

Evanston Northwestern Hospital

🇺🇸

Evanston, Illinois, United States

Renal Physicians of Georgia

🇺🇸

Macon, Georgia, United States

Research by Design, LLC

🇺🇸

Evergreen Park, Illinois, United States

Nephrology Inc.

🇺🇸

Mishawaka, Indiana, United States

Winthrop Dialysis Center

🇺🇸

Mineola, New York, United States

SUNY at Stony Brook NY

🇺🇸

Stony Brook, New York, United States

Wake Nephrology Associates

🇺🇸

Raleigh, North Carolina, United States

Southeastern Nephrology Associates

🇺🇸

Wilmington, North Carolina, United States

Carolina Nephrology, PA

🇺🇸

Greenville, South Carolina, United States

KfH Nierenzentrum/Bad/Konig

🇩🇪

Bad Konig, Germany

Alexandria Kidney

🇺🇸

Alexandria, Virginia, United States

Clinical Research & Consulting Center, LLC

🇺🇸

Fairfax, Virginia, United States

KfH Nierenzentrum

🇩🇪

Berlin, Germany

KfH Dialysezentrum/Berlin

🇩🇪

Berlin, Germany

KfH Nierenzentrum/Dulmen

🇩🇪

Dulmen, Germany

Georg-August-Universitat Universitatsmedizin Abt. Nephrologie u. Rheumatologie

🇩🇪

Gottingen, Germany

Dialysezentrum Barmbeck

🇩🇪

Hamburg, Germany

KfH-Dialysezentrum/Rosenheim

🇩🇪

Rosenheim, Germany

KfH-Nierenzentrum/Jena

🇩🇪

Jena, Germany

Churchill Hospital Oxford Kidney Unit

🇬🇧

Oxford, United Kingdom

Northwest Renal Clinic

🇺🇸

Portland, Oregon, United States

AKDHC Medical Research Services, LLC

🇺🇸

Phoenix, Arizona, United States

Creighton University Medical Center

🇺🇸

Omaha, Nebraska, United States

Shands University of Florida Outpatient Dialysis

🇺🇸

Gainesville, Florida, United States

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