Association of Multiple CardiOvascular Risk Factors and Erectile Function Across Europe
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 1,200
- Locations
- 4
Study Overview
Brief Summary
The purpose of the study is to evaluate the influence of cardiovascular risk factors, heart failure and cardiovascular drug therapy on erectile function in cardiovascular high-risk patients.
Detailed Description
Association of cardiovascular risk factors and ED is likely due to an impairment of endothelial function resulting in a decreased activity of endothelial NO-synthase, which plays a major role in physiology of erection. Heart failure is also known to further contribute to endothelial dysfunction and hence, this could lead to erectile dysfunction.
Study Objectives
- Evaluation of the influence of cardiovascular risk factors and concomitant medication on erectile function in cardiovascular high-risk patients.
- Evaluation of the role of heart failure on prevalence and severity of erectile dysfunction in men.
- Long-term effects of cardiovascular drug therapy and cardiovascular diseases on erectile function.
Study Design Male patients across Europe with cardiovascular diseases (CHD, PAD and heart failure) will be evaluated with a standardized questionnaire. Grade of erectile dysfunction will be assessed using an ED-score, generated from two different questionnaires.
- IIEF-5 - (International Index of Erectile Function)
- KEED - (Cologne Evaluation of Erectile Dysfunction)
Study Design
- Study Type
- Observational
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Male patients with two or more cardiovascular risk factors or
- •Male patients with a manifestation of atherosclerosis or
- •Male patients with an ischemic or dilated cardiomyopathy
- •Written informed consent
Exclusion Criteria
- •Impairment of hormonal status
- •Refusal of written informed consent
- •Inability to complete the questionnaires