S wave variability to assess fluid responsiveness in critically ill patients: a pilot trial.

• Conditions: Hypotensive ICU patients; Hemodinamically unstable ICU patients requiring fluid administration; Critical Illness; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12616001431415
• Lead Sponsor: Antonio Messina, MD, PhD

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-10-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Critically ill patients with an acute circulatory failure under conventional mechanical ventilation for whom the attending clinician had decided to administer fluid. This decision is based on the presence of at least one clinical sign of inadequate tissue perfusion in the absence of contraindication for fluid infusion.
Clinical signs of inadequate tissue perfusion are defined as
1) systolic blood pressure 90 mm Hg (or a decrease 50 mm Hg in previously hypertensive patients) or the need of vasopressive drugs (dopamine 5 mcg/kg/min or norepinephrine),
2) urine output 0.5 mL/kg/hr for at least 2 hrs,
3) tachycardia (heart rate HR 100/min)
4) presence of skin mottling

Exclusion Criteria

1) cardiac arrhythmias of any type.
2) moderate to severe ARDS
3) moderate to severe valvulopathies
4) inadequate acoustic window

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the area under the curve (AUC) of the s wave variability and pulse pressure variation[The end of fluid challenge administration. Approximatively 1h after enrollment.<br>There is a single time point, indicated by the end of the fluid challenge.]

Secondary Outcome Measures

Name	Time	Method
To assess the sensitivity of s wave variability in comparison to pulse pressure variation[The end of fluid challenge administration. Approximatively 1h after enrollment.<br>Single Timepoint];To assess specificity of s wave variability in comparison to pulse pressure variation[The end of fluid challenge administration. Approximatively 1h after enrollment.<br>Single Timepoint];To assess the reproducibility of tissue doppler evaluation between operators[Post-hoc analysis. End of enrollment.]