Effect of Cardiac Preconditioning Upon the Inotrope Score
- Conditions
- PreconditioningOpen Heart Surgery
- Interventions
- Procedure: ischemic preconditioning
- Registration Number
- NCT03105089
- Lead Sponsor
- Assiut University
- Brief Summary
preconditioning of no debate has a valuable effect upon myocardial protection . pre-cardiopulmonary bypass pre-conditioning , suspected to have a role upon postoperative inotropic support
- Detailed Description
Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ;pharmacologic or Physical) Pharmacological pc may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc ) Ischemic pc includes local ;remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs The liberated mediators have favorable effects not only upon the myocardium But ;it extend to protect other organs against inflammatory activation ;ischemia reperfusion injury Inotropic score IS is already an evident predictor of postoperative cardiac mobidity and mortality
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- adult patient
- valve replacement surgery
- ASA grade 2 or 3
- emergency surgery
-
- poor general conditions
- impaired hepatic or renal function
- peripheral vascular disease
- patient refusal
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ischemic preconditioning ischemic preconditioning ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles
- Primary Outcome Measures
Name Time Method inotropic score 48 hours
- Secondary Outcome Measures
Name Time Method renal function 2 dyas serum creatinine
Trial Locations
- Locations (1)
Emad Zarief Kamel Said
🇪🇬Assiut, Egypt