Remote Ischemic Preconditioning With Postconditioning in Heart Transplantation Surgery

Not Applicable

Completed

• Conditions: End Stage Heart Disease; Heart Failure; Myocardial Ischemic Reperfusion Injury; Cardiomyopathy
• Interventions: Procedure: control; Procedure: RIPC+RIPostC

• Registration Number: NCT02149316
• Lead Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital

Brief Summary

The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-05-26
• Study First Submitted QC: 2014-05-26
• Study First Posted: 2014-05-29
• Primary Completion: 2016-02
• Study Completion: 2016-02
• Status Verified: 2016-12
• Last Update Submitted: 2016-12-22
• Last Update Posted: 2016-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• scheduled for elective orthotopic heart transplantation surgery

Exclusion Criteria

• peripheral vascular disease affecting the upper arms
• mechanical circulatory support before surgery
• taking the antidiabetic sulphonylurea, glibenclamide
• cold ischemic time of donor heart > 12 hours
• repeated heart surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control	control	-
RIPC+RIPostC	RIPC+RIPostC	-

Primary Outcome Measures

Name	Time	Method
serum cardiac troponin I (cTnI)	within 72 hours after aortic declamping

Secondary Outcome Measures

Name	Time	Method
plasma microRNA-133b (miR-133b)	within 72 hours after aortic declamping
plasma microRNA-208a (miR-208a)	within 72 hours after aortic declamping

Trial Locations

Locations (1)

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS and PUMC; 🇨🇳 Beijing, China