Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery

Not Applicable

Completed

• Conditions: Heart Valve Diseases
• Interventions: Procedure: remote ischaemic preconditioning

• Registration Number: NCT01175681
• Lead Sponsor: Sun Yat-sen University

Brief Summary

Remote ischaemic preconditioning has shown its cardiac protective effect during heart surgery including coronary artery bypass graft surgery, congenital heart disease and aneurysm. However, no data was reported on heart valve disease surgery. Rheumatic heart disease is one of the major heart diseases requiring surgery in China. Thus, the investigators chose heart valve disease as a focus to see whether remote ischaemic preconditioning also has cardiac protective effect during heart valve surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-12
• Status Verified: 2010-07
• Study First Submitted: 2010-08-03
• Study First Submitted QC: 2010-08-04
• Study First Posted: 2010-08-05
• Primary Completion: 2011-03
• Study Completion: 2011-06
• Last Update Submitted: 2011-07-20
• Last Update Posted: 2011-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 73

Inclusion Criteria

• All heart valve diseases needing heart valve surgery.

Exclusion Criteria

• All four limbs existed ischemic condition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
treatment	remote ischaemic preconditioning	remote ischaemic preconditioning

Primary Outcome Measures

Name	Time	Method
plasma troponin I level	with 7 days after surgery	The investigators will measure the plasma troponin I level in several time points before and after surgery in each patient.

Secondary Outcome Measures

Name	Time	Method
serum creatinine	within 7 days after surgery

Trial Locations

Locations (1)

Guangzhou First Municipal People's Hospital; 🇨🇳 Guangzhou, Guangdong, China