Clinical Value of Remote Ischemic Preconditioning

Not Applicable

Completed

• Conditions: Atrial Fibrillation; Heart Diseases
• Interventions: Procedure: RIPC

• Registration Number: NCT01740102
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary. Remote ischemic preconditioning (RIPC) is an easy and non-invasive method. Laboratory research has shown promising results regarding myocardial survival during open heart surgery, but the clinical value of RIPC is still largely unknown. The investigators hypothesize that RIPC before coronary artery bypass grafting (CABG) reduces the incidence of postoperative atrial fibrillation (POAF).

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08
• Study First Submitted: 2012-11-21
• Study First Submitted QC: 2012-12-03
• Study First Posted: 2012-12-04
• Primary Completion: 2013-01
• Study Completion: 2013-09
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-03
• Last Update Posted: 2016-08-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

• Elective isolated on-pump CABG surgery
• Informed consent

Exclusion Criteria

• Patients with a severe pulmonary disease
• Patients with renal failure (GFR<30 mL/min/1.73 m2)
• Patients with liver failure
• Peripheral vascular disease affecting the upper limbs
• Patients on sulfonylurea derivatives.
• Patients with atrial fibrillation in their case history
• Prior cardiac surgery (Re-operations)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RIPC	RIPC	Remote ischemic preconditioning (RIPC) in the operating theatre after induction of anaesthesia and before surgery.

Primary Outcome Measures

Name	Time	Method
Postoperative atrial fibrillation	Up to 10 days after surgery	A patient will be classified as belonging to the postoperative atrial fibrillation group if they have any episode of atrial fibrillation, measured by telemetry, lasting more than 1 minute during their postoperative days at the hospital.

Secondary Outcome Measures

Name	Time	Method
Length of hospital stay	Maximum 14 days

Trial Locations

Locations (1)

St Olavs Hospital Trondheim University Hospital; 🇳🇴 Trondheim, Norway