Effect of Remote Ischemic Preconditioning on Cardiac Function After Cardiac Surgery

Phase 1

Withdrawn

• Conditions: Myocardial Injury; Cardiac Function; Atrial Fibrillation; Ventricular Arrythmias
• Interventions: Procedure: Remote Ischemic Preconditioning; Procedure: Control/sham procedure

• Registration Number: NCT00882622
• Lead Sponsor: Patrick Meybohm

Brief Summary

The purpose of this study is to evaluate the effects of Remote Ischemic Preconditioning on cardiac function in patients undergoing cardiac surgery compared to control intervention.

Detailed Description

In detail, we will focus on new onset of atrial fibrillation, ventricular arrhythmias, myocardial injury, and cardiac function. Furthermore, we aim to investigate underlying pathways of RIPC in modifying the perioperative stress response.

Study Timeline

• Study Start: 2009-02
• Primary Completion: 2009-02
• Study Completion: 2009-02
• Study First Submitted: 2009-04-14
• Study First Submitted QC: 2009-04-15
• Study First Posted: 2009-04-16
• Status Verified: 2012-01
• Last Update Submitted: 2012-01-17
• Last Update Posted: 2012-01-18

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patient undergoing heart surgery on cardiopulmonary bypass

Exclusion Criteria

• Emergency cases
• Myocardial infarction up to 7 days prior to enrollment
• Ejection fraction less than 30%
• Inability to give informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RIPC	Remote Ischemic Preconditioning	-
CONTROL	Control/sham procedure	-

Primary Outcome Measures

Name	Time	Method
New onset of atrial fibrillation	Within 30 days after surgery

Secondary Outcome Measures

Name	Time	Method
Ventricular arrhythmias, myocardial injury, cardiac function. Underlying pathways of Remote Ischemic Preconditioning in modifying the perioperative stress response.	Within 24 hours after surgery

Trial Locations

Locations (2)

University Hospital Schleswig-Holstein; 🇩🇪 Kiel, Germany

University Hospital; 🇩🇪 Frankfurt am Main, Germany