Total Body Perfusion in Patients With Chest Pain
Recruiting
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT05825859
- Lead Sponsor
- Turku University Hospital
- Brief Summary
The Purpose of this study is to better understand changes in obstructive coronary artery disease in different organs other than the heart such as the brain and the kidneys using a new generation total body PET scanner.
- Detailed Description
Patients with chest pain and suspected CAD will be studied using total body PET imaging with O15-water perfusion imaging
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- Documented history of chest pain with CT imaging showing a potential for obstructive coronary artery disease
- Ability to sustain adenosine injection 0.14 mg/kg/min
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Exclusion Criteria
- Second or third degree AV-block without pacemaker
- Sick sinus syndrome
- Consumption of coffee or aminophylline within 12 hours of administration
- Recent use of dipyridmole or dipyridamole-containing medications
- Known hypersensitivity to adenosine
- Unstable acute MI or acute coronary artery syndrome, and prior cardiac transplantation
- Active wheezing and bronchospasm
- Sinus bradycardia with HR<40 bmp
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Perfusion in heart, brain and kidneys during rest and adenosine stress, and their associations with psychologic factors and anginal symptoms The imaging day Multiorgan perfusion changes in patients with chest pain
- Secondary Outcome Measures
Name Time Method The association between perfusion in heart, brain and kidneys, and adverse events during five year follow-up Five year follow-up after the imaging Multiorgan perfusion changes in patients with chest pain as related to outcome
Trial Locations
- Locations (1)
Turku University Hospital
🇫🇮Turku, Finland