Serum Lipid Profile and Lip Squamous Cell Carcinoma

Completed

• Conditions: Lipid Profile; Lipids; SCC - Squamous Cell Carcinoma; Lip Cancer; Oral Cancer

• Registration Number: NCT07005115
• Lead Sponsor: Akdeniz University

Brief Summary

The goal of this observational retrospective study is to assess whether serum lipid levels differ between patients diagnosed with lip squamous cell carcinoma (SCC) and healthy individuals. The study aims to evaluate if alterations in lipid parameters, especially LDL levels, are associated with the presence of lip SCC and could serve as potential early biomarkers.

The main research questions are:

Do patients with lip SCC show significantly lower LDL levels compared to healthy controls? Are there significant differences in total cholesterol (TC), triglycerides (TG), HDL, and VLDL between the two groups? A retrospective analysis was conducted using existing medical records of patients with lip SCC and healthy subjects obtained from 2018-2023.

Detailed Description

Demographic data and lipid profile information were collected from 56 patients (28 lip SCC and 28 healthy). The lipid parameters included were total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low-density lipoprotein (VLDL).

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2021-01-01
• Study Completion: 2023-01-01
• Study First Submitted: 2025-05-27
• Study First Submitted QC: 2025-05-27
• Status Verified: 2025-06
• Study First Posted: 2025-06-05
• Last Update Submitted: 2025-06-05
• Last Update Posted: 2025-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• patients clinically evident and histopathologically confirmed with lip SCC (study group)
• subjects without any underlying systemic disease (control group)

Exclusion Criteria

• Age younger than 18 years
• pregnancy
• smoking
• history of radiotherapy or chemotherapy
• family history of hyperlipidemia
• accompanying malignancies other than lip SCC for both study and control groups

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Low-Density Lipoprotein (LDL) Levels in Patients With Lip SCC vs. Healthy Controls	At time of diagnosis (retrospective data collection)	To assess whether there is a statistically significant difference in fasting serum LDL levels between patients diagnosed with lip squamous cell carcinoma (SCC) and healthy subjects.

Secondary Outcome Measures

Name	Time	Method
High-Density Lipoprotein (HDL) Levels in Patients With Lip SCC vs. Healthy Controls	At time of diagnosis (retrospective data collection)	To compare HDL levels between lip SCC patients and healthy controls.
Very Low-Density Lipoprotein (VLDL) Levels in Patients With Lip SCC vs. Healthy Controls	At time of diagnosis (retrospective data collection)	To compare fasting serum VLDL levels between study and control groups.
Total Cholesterol (TC) Levels in Patients With Lip SCC vs. Healthy Controls	At time of diagnosis (retrospective data collection)	To compare fasting serum total cholesterol (TC) levels between lip SCC patients and healthy controls.
Triglycerides (TG) Levels in Patients With Lip SCC vs. Healthy Controls	At time of diagnosis (retrospective data collection)	To evaluate fasting serum TG levels in lip SCC patients compared to controls.

Trial Locations

Locations (1)

Akdeniz University; 🇹🇷 Antalya, Turkey