Short Term Outcomes in Hospitalized Patients With Liver Cirrhosis

Recruiting

• Conditions: Liver Cirrhosis

• Registration Number: NCT05848414
• Lead Sponsor: Assiut University

Brief Summary

This study will be conducted to assess the baseline characteristics and evaluate the 90-day mortality of patients admitted with liver cirrhosis. Also, the study will be done to identify the risk factors of 90-day mortality.

Detailed Description

Liver cirrhosis is the end spectrum of all chronic liver diseases characterized by advanced fibrosis, scarring, and formation of regenerative nodules leading to hepatic architectural distortion.

Liver cirrhosis is a major cause of health burden worldwide. According to the Global Burden of Disease study, liver cirrhosis caused 1.2% of global disability-adjusted life years and 2% of all deaths worldwide in 2010, the 14th leading cause of mortality.

The progress rate of compensated cirrhosis to decompensated cirrhosis is approximately 58% and once it progresses to decompensated cirrhosis, its mortality rate within 5 years becomes 85% without liver transplantation. Since the progression of cirrhosis is accelerated each time a complication recurs, the management and treatment of the complication are critical in enhancing the quality of life and the life expectancy of patients .

Post-discharge outcomes are an integral component of healthcare, as they may aid in determining the success and longevity of treatment and how clinicians approach future cases .

This study will focus on the short-term outcomes of patients hospitalized with liver cirrhosis to provide insight into methods for future healthcare interventions.

Study Timeline

• Study First Submitted: 2023-03-28
• Study First Submitted QC: 2023-04-27
• Study First Posted: 2023-05-08
• Study Start: 2024-02-07
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-29
• Last Update Posted: 2024-07-30
• Primary Completion: 2025-05-07
• Study Completion: 2025-07-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• diagnosis of liver cirrhosis, adult (age ≥ 18 years old) and patients willing to give consent during the selected period.

Exclusion Criteria

• Patients with ages < 18 years or patients that will be lost on follow-up will be excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evaluate the 90-day mortality of patients admitted with liver cirrhosis	90 days	Mortality

Secondary Outcome Measures

Name	Time	Method
identify the risk factors of 90-day mortalit	90 days	Risk factors for mortality

Trial Locations

Locations (1)

Esraa Hassan Mohamed Kotbey; 🇪🇬 Assiut, Egypt