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Clinical Trials/NCT06287554
NCT06287554
Completed
Not Applicable

Effect of Early Implementation of Prone Positioning Among Critically Ill Patients Admitted With Acute Respiratory Distress Syndrome During the COVID-19 Time: A Comparative Retrospective Observational Study

Zulekha Hospitals1 site in 1 country70 target enrollmentMarch 4, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Severe Acute Respiratory Syndrome
Sponsor
Zulekha Hospitals
Enrollment
70
Locations
1
Primary Endpoint
Number of discharged patients
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

Background and objective: The ramifications of early lung protective measures and prone positioning on the ICU length of stay rates of participants admitted to the ICU with acute respiratory distress syndrome amid the COVID-19 pandemic constitute a pivotal examination. The study aims to identify the effect of early prone positioning on the length of stay, discharge rate, and number of tracheostomized patients in the ICU.

Detailed Description

Background and objective: The ramifications of early lung protective measures and prone positioning on the ICU length of stay rates of participants admitted to the ICU with acute respiratory distress syndrome amid the COVID-19 pandemic constitute a pivotal examination. The study aims to identify the effect of early prone positioning on the length of stay, discharge rate, and number of tracheostomized patients in the ICU. Methodology: This retrospective study was conducted on critically ill patients needing mechanical ventilation with lung protective strategy and admitted to the Intensive Care Units of Al-Azhar University Hospitals between March 2020 to April 2022. All patients in the study were interpreted retrospectively by examining the patient's records. Group A (n:39) included patients who had been early placed in prone positions within 24 hours of intubation, and Group B (n:31) included patients who had not been placed in prone positions. All patients received a lung protective strategy for ARDS. In both groups, PaO2, PaCo2, PH, SpO2, and PaO2/FiO2 ratio were checked initially and later every 24 hours for 6 days. All patients were evaluated for the total days of both hospital and ICU length of stay, number of successful discharges to home from the hospital, and the total number of tracheostomized patients.

Registry
clinicaltrials.gov
Start Date
March 4, 2020
End Date
April 20, 2022
Last Updated
2 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Zulekha Hospitals
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • All patients of both sexes.
  • Aged from 18 to 70 years.
  • Body Mass Index (BMI) from 25 to 35 kg/m
  • Critically ill due to ARDS resulting from COVID-19 pneumonia.

Exclusion Criteria

  • Patients who spent more than 24 hours on mechanical ventilators before enrolment in the study.
  • Patients who died within the first 24 hours of presentation.
  • Patients with advanced cancer.
  • Pregnant patients.

Outcomes

Primary Outcomes

Number of discharged patients

Time Frame: 26 MONTHS

Number of discharged patients

Secondary Outcomes

  • Patients who underwent tracheostomy procedures(26 MONTHS)
  • ICU length of stay(26 MONTHS)
  • The total length of stay(26 MONTHS)

Study Sites (1)

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