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临床试验/NCT06857630
NCT06857630招募中不适用

The Association Between Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery: A Prospective Observational Study

Samsun University1 个研究点 分布在 1 个国家目标入组 420 人开始时间: 2025年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
420
试验地点
1
主要终点
Acute renal failure.

研究概览

简要总结

Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood transfusion or various interventions to increase hemoglobin levels on outcomes continue to be debated. The effects of hemoglobin levels in emergency surgery patients on the development of postoperative AKI have been investigated in a small number of studies in the literature, and clear results have not yet been reported. This study was designed to evaluate the effect of hemoglobin levels on the development of AKI after adjustment for known predictive factors.

详细描述

Acute kidney injury (AKI) is a common complication in patients undergoing major surgery and is associated with both short-term morbidity and mortality and long-term adverse outcomes including the development of Chronic Kidney Failure. Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of various interventions such as blood transfusion or increasing hemoglobin levels on outcomes continue to be debated. This prospective observational study was planned to evaluate the effect of hemoglobin levels before emergency surgery on the development of postoperative AKI.

Emergency operated patients will be divided into two groups as Group AKI and Group non-AKI according to the development of postoperative renal failure. Postoperative AKI diagnosis and severity will be evaluated according to serum creatinine and/or urine output according to KDIGO (Kidney Disease: Improving Global Outcomes criteria).

Demographic characteristics of the patients, preoperative complete blood count, blood biochemistry characteristics, hemodynamic variables, fluid replacement, blood and blood product replacements, surgical characteristics, development and severity of AKI in the postoperative period will be recorded and the effect of hemoglobin level on the development of AKI will be evaluated.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Patients undergoing emergency non-cardiac surgery

排除标准

  • •Known renal failure
  • •Need for reoperation within 48 hours postoperatively
  • •Exit status within 48 hours postoperatively
  • •Known hematological disease
  • •Known kidney transplantation
  • •Urgent surgery planned due to urinary system related diseases
  • •Patients who did not accept to participate in the study

研究组 & 干预措施

Group AKI

Postoperative renal failure

干预措施: Observational (Other)

Group non-AKI

Postoperative non renal failure

干预措施: Observational (Other)

结局指标

主要结局

Acute renal failure.

时间窗: 72 hours

The effect of hemoglobin level before emergency surgery on the development of postoperative acute renal failure.

次要结局

  • Hospital days(1 month)

研究者

发起方
Samsun University
申办方类型
Other
责任方
Sponsor

研究点 (1)

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