Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery

Completed

• Conditions: Acute Kidney Injury
• Interventions: Diagnostic Test: increase in serum creatinine

• Registration Number: NCT05390281
• Lead Sponsor: Ain Shams University

Brief Summary

Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG).

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-01
• Primary Completion: 2020-07-01
• Study Completion: 2020-10-01
• Status Verified: 2022-05
• Study First Submitted: 2022-05-14
• Study First Submitted QC: 2022-05-22
• Last Update Submitted: 2022-05-22
• Study First Posted: 2022-05-25
• Last Update Posted: 2022-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• ASA physical status II-III
• scheduled to undergo isolated coronary artery bypass grafting

Read More

Exclusion Criteria

• Patients with history of renal failure
• Patients with history of hepatic failure
• Patients with history of heart failure
• previous cardiac surgery
• cerebrovascular event in the last 30 days
• percutaneous coronary intervention in the last 30 days prior to operation
• peripheral arterial disease
• malignancy
• infectious diseases
• patients who required surgical revision
• patients who required postoperative intra-aortic balloon pump
• patients with CBP time > 120 min or aortic cross clamp time > 90 min

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pre-diabetic group	increase in serum creatinine	Patients with preoperative HbA1c 5.7-6.4% (group A) (prediabetics)
Diabetic group	increase in serum creatinine	Patients with preoperative HbA1c \> or = 6.5% till 7% or \> 7% in case of emergency surgery or rapidly progressive cases with no time for long-term glycemic control (group B) (diabetics)

Primary Outcome Measures

Name	Time	Method
serum creatinine level	3 days	increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinine to ≥ 1.5 times baseline within 3 days of cardiac surgery

Secondary Outcome Measures

Name	Time	Method
Patients in need of RRT	7 days	The number of patients requiring postoperative renal replacement therapy

Trial Locations

Locations (1)

Ain-Shams University; 🇪🇬 Cairo, Egypt