Association Between Hematological Ratios and Acute Kidney Injury After Cardiovascular Surgery in Neonates: a Retrospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Acute Kidney Injury (AKI)
研究概览
简要总结
Acute kidney injury (AKI) is a common complication after surgery for congenital heart disease and is associated with significant morbidity and mortality. To-date, no biomarker has been universally implemented for predicting AKI in neonates after cardiac surgery. In this study, the use of hematological ratios will be evaluated for predicting AKI and postoperative outcomes in this patient cohort.
详细描述
In adults, hematological ratios which can be calculated from a routinely ordered complete blood count with differential, such as the neutrophil/lymphocyte ratio, have been demonstrated to be correlated with acute kidney injury (AKI) and other clinical outcomes after cardiovascular surgery. In this retrospective observational study, the association between hematological ratios (neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, neutrophil/lymphocyte*platelet ratio, monocyte/lymphocyte ratio, and plateletcrit) and postoperative AKI, morbidity (length of ICU stay, hospital stay, mechanical ventilation, vasoactive infusion-free days, etc.) and mortality will be evaluated in neonates who underwent cardiac surgery with cardiopulmonary bypass.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Days 至 31 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Neonates (≤31 days) who underwent cardiac surgery with cardiopulmonary bypass for congenital heart disease.
排除标准
- •Patients with missing relevant preoperative or postoperative data points
- •Patients with previous palliation or reoperation,
- •Thymus hypo/aplasia (DiGeorge Syndrome, Ataxia-telangiectasia, or Nezelof syndrome),
- •Primary immunodeficiency,
- •Episode of cardiac arrest within 1 week before surgery,
- •Signs or history of preoperative renal impairment or AKI (KDIGO Stage ≥1 observed on preoperative labs),
- •Hypothyroidism,
- •Patients with a history of infection within a week prior to surgery or antibiotics administered within the first 3 days after surgery (except for postoperative antibiotics).
结局指标
主要结局
Acute Kidney Injury (AKI)
时间窗: up to 72 hours postoperative
Occurrence of AKI as defined by the Kidney Disease Improving Global Outcomes (KDIGO) diagnostic classification (using serum creatinine)
次要结局
- Operative Mortality(up to 30 days postoperative)
- Length of Cardiac Intensive Care Unit (CICU) Stay(up to 1 year postoperative)
- Low Cardiac Output Syndrome(up to 2 days postoperative)
- 1-year mortality(up to 1 year postoperative)
- Length of hospital stay(up to 1 year postoperative)
- Vasoactive infusion-free days(up to 28 days postoperative)
- Length of mechanical ventilation(up to 1 year postoperative)
- Postoperative infection(up to 3 days postoperative)