Levosimendan Versus Milrinone in Off Pump CABG Surgery
- Registration Number
- NCT03855579
- Lead Sponsor
- Assiut University
- Brief Summary
To compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.
- Detailed Description
The major challenge during off-pump coronary artery bypass graft surgery is to maintain optimum hemodynamics by optimizing the intravascular volume and by using some inotropes. However, conventional inotropes such as beta-agonists are associated with tachycardia and arrhythmia which increase myocardial oxygen demand.
Levosimendan is an inodilator which exerts its positive inotropic effect by enhancing the sensitivity of troponin C to calcium without increasing intracellular calcium concentration. Levosimendan also decreases the systemic vascular resistance, so, it increases the cardiac output without increasing myocardial oxygen consumption.
This study aims to compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Elective off-pump coronary artery bypass grafting surgery.
- ejection fraction < 50%
- Patients with severe renal impairment or renal failure.
- Patients on mechanical support (intra-aortic balloon pump)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Levosimendan Levosimendan Intraoperative infusion of Levosimendan Milrinone Milrinone Intraoperative infusion of Milrinone
- Primary Outcome Measures
Name Time Method Mean blood pressure Intraoperative Consumption of other inotropes Intraoperative
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assiut University
🇪🇬Assiut, Egypt