Can oxygen delivered into the nose (rather than through a face mask) improve oxygen levels at the start of anesthesia in obese patients undergoing surgery?

Not Applicable

Completed

• Conditions: Pre-intubation apnea following anesthesia in obese patients undergoing bariatric surgery; Injury, Occupational Diseases, Poisoning

• Registration Number: ISRCTN37375068
• Lead Sponsor: ppsala Regional Council

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34309839/ (added 10/09/2021) 2022 Results article in https://doi.org/10.1002/hsr2.616 (added 17/11/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-10-23
• Study Completion: 2020-03-15
• Last Update Posted: 28 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Patients undergoing bariatric surgery due to morbid obesity
2. American Society of Anesthesiologists (ASA) Classification I or II
3. Able to understand participant information sheet and give written consent

Exclusion Criteria

1. New York Heart Association (NYHA) Functional Classification >II
2. COPD or asthma causing restrictions in daily activities
3. Restrictive lung disease associated with a reduction of total lung capacity (TLC) of >20%
4. Allergy to any of the anesthetic agents used in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. End-tidal oxygen concentration (EtO2) in breath measured at baseline, every 2.5 min until 10 min and after tracheal intubation by the ventilator (Maquet FLOW-i®)<br>2. Blood gases measured at baseline, every 2.5 minutes until 10 minutes and after tracheal intubation using Abbott's i-STAT®1 portable blood gas analyser. Blood gases are also measured on arrival at the postoperative ward and at 30 and 60 min after arrival.

Secondary Outcome Measures

Name	Time	Method
1. End-tidal carbon dioxide concentration (EtCO2) in breath measured by the ventilator (Maquet FLOW-i®)<br>2. Peripheral capillary oxygen saturation (SpO2; a measure of haemoglobin oxygenation in blood) measured using the Draeger Infinity® Delta monitor<br>3. Heart rate measured using the Draeger Infinity® Delta monitor<br>4. Blood pressure measured using the Draeger Infinity® Delta monitor<br>All secondary outcome measures are measured at baseline, every 2.5 min until 10 min and after tracheal intubation.