Enhancing effects of yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1 on antibody production against influenza vaccine

Not Applicable

• Conditions: /A (Healthy adults)

• Registration Number: JPRN-UMIN000040233
• Lead Sponsor: TES Holdings Co., Ltd.

Brief Summary

<Scientific conference> Japanese Association for Food Immunology 2014 Serum antibody titer specific to A H3N2 and B strain were significantly higher in tested food group than placebo group. Seroconversion rate of B strain was over 40 which was considered as positive only in tested food group.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2014-03-31
• Study Start: 2020-05-10
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

[1] Individuals who have gotten an allergic reaction to vaccination [2] Individuals who were vaccinated in either 2011/2012, 2012/2013 or 2013/2014 season [3] Individuals who were infected with influenza in either 2011/2012, 2012/2013 or 2013/2014 season [4] Individuals who were infected with influenza before vaccination [5] Individuals who have allergies to dairy products or lactose intolerance [6] Individuals who have a habit to take test food once a week or more in the past 3 months [7] Individuals who have allergies to foods or medicines [8] Individuals who have medical history of allergic diseases like pollinosis that require medications [9] Individuals who have immunodeficiency disease [10] Individuals who have medical history of malignant tumor [11] Individuals who have diabetes mellitus or dyslipidemia that require medications [12] Individuals who are taking medications for chronic diseases, which affect the result of this study [13] Individuals who have medical history of serious diseases that affect the result of this study [14] Individuals who participated in other clinical trials in the past 1 month or who are going to participate in other trials in this study period [15] Women who are going to be pregnant or breastfeeding in this study period [16] Individuals who are judged not suitable to participate in this trial by investigators

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
[1]Antibody titers specific to influenza vaccine antigen [2]Seroconversion rate [3]Mean geometric increase [4]Seroprotection