Serum Nectin-4 Levels in Patients With Early Onset Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- serum nectin-4 levels
研究概览
简要总结
Early-onset Preeclampsia (PE) is a pregnancy disorder which may present with adverse pregnancy outcomes. Nectin-4 is an adhesion molecule mainly expressed in placenta. This study aimed to evaluate the relationship between early onset Preeclampsia and serum Nectin 4 levels.
详细描述
Preeclampsia is assumed as a two-stage disorder arising from defective trophoblast invasion and failure of spiral artery remodeling as the main step responsible for the pathogenesis. PE is classified according to the disease onset time as early-onset PE before 34 weeks and late-onset PE after 34 weeks. Late-onset PE is more commonly seen and accepted as a mild maternal reaction to pregnancy. In early-onset PE, unlike the late-onset, due to the improper placental invasion, the diffuse placental ischemia and the resulting oxidative stress begin at early gestation. Thus, the early-onset PE may result in severe disease leading to perinatal and maternal morbidity and mortality.
The nectins are calcium-independent immunoglobulin-like celladhesion molecules and have a pivotal role at cellular junctions, as well as physiological regulations(8). Placenta expressesfor types of nectins; nectin-1, nectin-2, nectin-3, and nectin-4. They are localized at tight junctions and gap junctions of syncitiotrophoblasts(9). Nectin-4 is a relatively novel member of nectin family which has been detected only in placenta and airway epithelium in healthy subjects.
Despite, there has been no study published yet to reveal the soluble nectin-4 levels in preeclampsia as well as in early onset disease. In this study, we aimed to investigate the serum nectin-4 levels in early-onset preeclampsia in comparison of the healthy pregnancies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •spontaneous,
- •singleton pregnancies
- •above the 24 weeks of gestations
- •positive fetal cardiac activity
排除标准
- •multiple gestations,
- •chronic hypertension
- •hypothyroidism
- •known malignancy,- diabetes mellitus,
- •presence of fetal or maternal infection,
- •clinical signs of chorioamnionitis (maternal fever, vaginal discharge, fetal tachycardia),
- •hepatic or renal failure
- •Placenta previa or pregnancies accompanied congenital fetal abnormalities or aneuploidies
结局指标
主要结局
serum nectin-4 levels
时间窗: 1 hour
ng/ml
次要结局
- BMI (body mass index)(5 minute)
- Tansion Arterial(5 minute)
研究者
Hatice Akkaya
associate professor
Kayseri Education and Research Hospital
