Cirrhotic Patients With Septic Shock

Completed

• Conditions: Cirrhosis; Septic Shock
• Interventions: Other: Measure of short- and long-term mortality and analysis of independent predictors of short- and long-term mortality.

• Registration Number: NCT03987048
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Cirrhotic patients have a poor outcome in intensive care unit (ICU). Septic shock is a leading cause of ICU admission and death in this specific population. We performed a monocentric retrospective study; all cirrhotic patients admitted in the ICU with septic shock from 2002 to 2013 were included. The aim of the study was to identify prognostic factors for both short- and long-term mortality in these patients. Demographic, clinical and biological data, organ supports, and outcomes were collected. Univariate and multivariate analysis were carried out regarding both ICU and one-year mortality.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-04
• Primary Completion: 2015-04
• Study Completion: 2015-04
• Status Verified: 2019-05
• Study First Submitted: 2019-05-03
• Study First Submitted QC: 2019-06-13
• Last Update Submitted: 2019-06-13
• Study First Posted: 2019-06-14
• Last Update Posted: 2019-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 149

Inclusion Criteria

• age 18 or older
• diagnosis of cirrhosis
• diagnosis of septic shock at ICU admission

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Exclusion Criteria

• prior liver transplantation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cirrhotic patients with septic shock	Measure of short- and long-term mortality and analysis of independent predictors of short- and long-term mortality.	All consecutive adult cirrhotic patients admitted to the ICU with septic shock from 2002 to 2013.

Primary Outcome Measures

Name	Time	Method
Short-term outcome: analysis of independent predictors of ICU mortality rate.	Between ICU admission (from January 2002 to December 2013) and ICU discharge	The predictors assessed independently are the clinical data, site of infection, biological data, liver scoring systems, organ failure, organ support and simplified acute physiology score (SAPS II), expressed in percentage of patients.; The mortality rate is expressed in percentage of patients.
Long-term outcome: analysis of independent predictors of one-year mortality rate.	At one year after ICU admission (from January 2002 to December 2013)	The predictors assessed independently are the independent predictors found to be related to the short-term mortality rate, expressed in percentage of patients.; The mortality rate is expressed in percentage of patients.

Trial Locations

Locations (1)

Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot (HCL); 🇫🇷 Lyon, France