Practice of Mechanical Ventilation in Patients With Severe Brain Injury in China

Completed

• Conditions: Respiration, Artificial

• Registration Number: NCT02517073
• Lead Sponsor: Capital Medical University

Brief Summary

The mechanical ventilation strategy has changed over years worldwide. Several international researches have been conducted to study the association of the use of mechanical ventilation with clinical outcomes. In this prospective, multicenter, cross-sectional survey, the practice of mechanical ventilation among patients with severe brain injury will be investigated in 70 intensive care units in China.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08
• Primary Completion: 2015-08
• Study First Submitted: 2015-08-04
• Study First Submitted QC: 2015-08-04
• Study First Posted: 2015-08-06
• Study Completion: 2015-09
• Status Verified: 2016-01
• Last Update Submitted: 2016-01-26
• Last Update Posted: 2016-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

1. older than 18 years
2. with severe brain injury (including severe traumatic brain injury, ischemic stroke, subarachnoid hemorrhage, spontaneous intracerebral hemorrhage, hypoxic-ischemic encephalopathy, intracranial tumor, intracranial infection and idiopathic epilepsy)
3. mechanical ventilated for at least 24 hours before the time of on-spot survey

Exclusion Criteria

1. undergoing a spontaneous breathing trial (SBT) at the time of on-spot survey
2. underwent at least once SBT in the preceding 24 hours before time of on-spot survey
3. enrolled in another trial

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients receiving control and assist mode of mechanical ventilation	During 1 hour of on-spot survey	Control mode is defined as volume or pressure control ventilation. Assist mode is defined as synchronized intermittent mandatory ventilation and pressure support ventilation.

Secondary Outcome Measures

Name	Time	Method
Duration of mechanical ventilation	60 days after on-spot survey
Number of patients liberated from mechanical ventilation	60 days after on-spot survey
The settings of tidal volume, inspiratory pressure, and positive end-expiratory pressure in enrolled patients	During 1 hour of on-spot survey
Neurological outcome by Glasgow Outcome Scale	60 days after on-spot survey

Trial Locations

Locations (1)

ICU, Beijing Tiantan Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China