A randomised trial of ibuprofen in addition to usual care for cellulitis of the lower limb.
- Conditions
- ncomplicated cellulitis of the lower limbUncomplicated cellulitis of the lower limbInfection - Other infectious diseasesSkin - Other skin conditionsInflammatory and Immune System - Other inflammatory or immune system disorders
- Registration Number
- ACTRN12611000515998
- Lead Sponsor
- Dr Josh Davis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 46
1) Age >=18 years.
2) Uncomplicated lower limb cellulitis or erysipelas.
Cellulitis/erysipelas are defined as being present if the diagnosis has been made by an Infectious Diseases registrar or consultant.
The following will be considered complicated” and will thus not be eligible: Abscess requiring surgical intervention. Post-operative wound infection. Coexisting deep venous thrombosis. Suspected or proven necrotising fasciitis or gas gangrene. Cellulitis extending superior to the inguinal ligament.
3) Admitted directly to the Hospital in the Home unit from the emergency department or a referring GP.
4) Receiving intravaneous Cefazolin 2grams every 12 hours
5) Able to be randomised within 24 hours of the first dose of effective IV antibiotics.
1) Allergy to non-steroidal anti-inflammatory drugs including aspirin.
2) Definite history of current peptic ulcer or past complicated peptic ulcer.
3) Acute renal impairment (Serum Creatinine>120).
4) Chronic renal impairment with eGFR<50.
5) Current Varicella or zoster infection (chicken pox or shingles).
6) Iatrogenic immunosuppression.
7) Known pregnancy.
8) Currently taking regular anti-inflammatory drugs that cannot be ceased
9) Currently taking therapeutic anticoagulation or potent antiplatelet agents
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method