Cross Sectional Area of Umbilical Cord Versus Hadlock's Formula in Prediction of Neonatal Birth Weight

Completed

• Conditions: Birth Weight; Fetal Body Weight
• Interventions: Device: Obstetric ultrasound

• Registration Number: NCT05362175
• Lead Sponsor: Ain Shams University

Brief Summary

Ultrasound measurement of cross sectional area of umbilical cord might offer advantage over Hadlock's formula for accurate estimation of actual birth weight at term gestation leading to prevention of large number of maternal and neonatal morbidity and mortality.

Detailed Description

Umbilical cord is a vital structure of maternal-fetal life that can be used to evaluate pregnancy outcomes. In the past, sonographic investigations of the umbilical cord were limited to identification of the number of vessels and Doppler evaluation of the blood flow. Various formulas have developed to calculate Estimated Fetal Weight (EFW) using fetal biometry. While it is being accurate to a degree, they are associated with error especially with extreme birth weight. In this study using the ultrasound to look for a relation between the umbilical cord cross sectional area and estimated birth weight, as it's easy to use and readily available, comparing the estimated birth weight obtained by this method with that of Hadlock's formula measures at term gestation. Trying to prove that the umbilical cord area formula might gave advocacy for future usage for birth weight prediction.

Study Timeline

• Study Start: 2021-07-15
• Study First Submitted: 2021-08-26
• Primary Completion: 2022-04-15
• Study Completion: 2022-04-15
• Status Verified: 2022-05
• Study First Submitted QC: 2022-05-03
• Last Update Submitted: 2022-05-03
• Study First Posted: 2022-05-05
• Last Update Posted: 2022-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 220

Inclusion Criteria

• Pregnant women with:

  • Age: 18-35 years.
  • Singleton living fetus.
  • Term gestation (37wks_ 41wks+6days). (Spong , 2013).
  • Admitted at labor room or prepared for caesarean section

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Exclusion Criteria

• o Intrauterine Dead fetus (IUFD).

  • Structurally malformed fetus or umbilical cord (single umbilical artery; SUA).
  • Multiple pregnancies.
  • Oligohydraminos (AFI < 5cm or DVP <2 cm) or polyhydraminos (AFI > 25 cm or DVP > 8 cm) (Morteza et al., 2018).
  • Uterine fibroid.
  • Abnormal Doppler flowmetry of umbilical artery.
  • Maternal diseases (Diabetes mellitus, Hypertensive disorders, renal diseases, Ischemic heart diseases), history of drug intake (Antihypertensive, antiepileptic, oral hypoglycemic drugs).

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cross sectional area of umbilical cord and Hadlock's formula	Obstetric ultrasound	Ultrasound measurement of cross sectional area of umbilical cord within 1 cm from the umbilical cord insertion into the fetal abdomen And Fetal biometry using the standard Hadlock's formula

Primary Outcome Measures

Name	Time	Method
Estimated fetal weight calculation by hadlock's formula and by umbilical cord cross sectional area ,then correlation with actual birth weight measured with in 1st hour of delivary	1st hour of delivary	correlation with actual birth weight measured

Trial Locations

Locations (1)

Ain Shams university; 🇪🇬 Cairo, Egypt