Acute Effects of Breaking Prolonged Sitting on Postprandial Glycaemic Response, Incretin Hormones Secretion and Eating Behaviour in Overweight and Obese Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Gut hormones responses
研究概览
简要总结
The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary overweight and obese adults.
详细描述
Two trials are included in this project - Prolonged sitting and Breaking sitting.
In the Prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min. In the Breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. Blood samples were collected in a regular pattern throughout the trials. Energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Physical inactive males and females
- •Aged between 20 and 45 years
- •Overweight and obese healthy adults (waist circumference greater than 90 cm for males and 80 cm for females)
- •Weight stable for more than 3 months (no change in weight +/- 3%)
- •Non-smoker
- •Able to walk comfortably on a treadmill
排除标准
- •Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
- •Waist circumference < 90 cm for male and < 80 cm for female
- •Taking medications that may influence lipid or carbohydrate metabolism or immune system function
- •Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)
结局指标
主要结局
Gut hormones responses
时间窗: 320 minutes
Changes in blood gut hormones responses (e.g., GLP-1, PYY and GIP concentrations measured in pmol/L) between trials
次要结局
- Lipid profile(320 minutes)
- Visual analogue scale (VAS)(320 minutes)
- Computerized cognitive testing(320 minutes)
- Physical activity level(600 minutes after leaving the labalotory)
- Energy intake(600 minutes after leaving the labalotory)
- Incremental area under curve (iAUC) for metabolic health(320 minutes)
- Blood pressure(320 minutes)
研究者
Yung-Chih Chen
Principal Investigator
National Taiwan Normal University