Cardiac disease in Ankylosing Spondylitis
Recruiting
- Conditions
- Ankylosing spondylitis, osteoartritis
- Registration Number
- NL-OMON25008
- Lead Sponsor
- Reade
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 192
Inclusion Criteria
AS according to New York (1984) criteria
-Written informed consent
-Age 50-75 years
Exclusion Criteria
-Malignant disease
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diastolic dysfunction.<br>Diastolic dysfunction will be defined as follows: mild diastolic dysfunction (stage I—impaired relaxation). Characterized by an E/A ratio <1, Em/Am <1, prolonged DT (>240 ms), and IVRT (>110 ms). Em (<8 cm/s) is reduced. E/Em is <10. Moderate diastolic dysfunction (stage II— pseudo normalization). Characterized by an E/A ratio >1, Em/Am <1. Em (<8 cm/s) is reduced and E/Em is >10. Severe diastolic dysfunction (stage III— restrictive filling). This stage is characterized by an overt increased E/A ratio (>2), shortened DT (<150 ms), and IVRT (<60 ms). Em (<8 cm/s) remains at the lowest level. E/Em is >10. [13;20]
- Secondary Outcome Measures
Name Time Method Systolic dysfunction: Systolic dysfunction will be defined as an ejection fraction of <50%.