Compare the Analgesic Effect of Different Anesthesia and Postoperative Analgesic Methods in Uniportal VATS Lung Surgery

Phase 1

• Conditions: Postoperative Pain; Single-incision Thoracoscopic Surgery
• Interventions: Combination Product: epidural anesthesia; Combination Product: general anesthesia

• Registration Number: NCT03311737
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

This is a single center, randomized, single blind study to compare the analgesic effect of different anesthesia and postoperative analgesic methods in uniportal VATS lung surgery.

Detailed Description

Combining epidural with general anesthesia is regarded as the gold standard of general thoracic surgery. The uniportal VATS lung surgery have advantages of minimal invasive surgical incision, less postoperative pain, and so on. Whether general anesthesia can become an alternative method of combining epidural with general anesthesia in uniportal VATS lung surgery, investigators thus plan to make a comparison on intraoperative stress response, postoperative pain, immune function of patients，and hospital expenses.

Study Timeline

• Status Verified: 2017-09
• Study Start: 2017-09-19
• Study First Submitted: 2017-09-23
• Study First Submitted QC: 2017-10-14
• Last Update Submitted: 2017-10-14
• Study First Posted: 2017-10-17
• Last Update Posted: 2017-10-17
• Primary Completion: 2018-03-31
• Study Completion: 2018-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients elective uniportal VATS lung surgery;
• BMI 18-30 kg/m2.

Exclusion Criteria

• Patient refuse;
• ASA≥3;
• Patients allergic to use anesthetics (propofol,rocuronium), patients with liver and/or kidney and/or mental dysfunction.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
epidural group	epidural anesthesia	The patients in this group receive general anesthesia combined with epidural anesthesia, and use patient controlled epidural analgesia postoperatively.
general anesthesia group	general anesthesia	The patients in this group receive general anesthesia preoperatively, and use patient controlled intravenous analgesia postoperatively.

Primary Outcome Measures

Name	Time	Method
visual analogue scale（VAS）	1 year	This scale mainly reflects the patient's pain

Trial Locations

Locations (1)

Zhongshan Hospital; 🇨🇳 Shanghai, Shanghai, China