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临床试验/CTRI/2024/07/070633
CTRI/2024/07/070633已完成2/3 期

to evaluate the efficacy of prachchhana karma and lodhradi pratisarana with and without adjuvant drug chandanandi kwatha orally in the treatment of dantaveshta w.s.r. to periodontitis – an open label randomised comparative clinical study

Government Akhandanand Ayurved College1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年8月1日最近更新:

试验速览

阶段
2/3 期
状态
已完成
发起方
入组人数
30
试验地点
1
主要终点
To reduce the symptoms of dantaveshta.

研究概览

简要总结

In  Mukharoga, Aacharya Sushruta has explained about Dantaveshta. It occurs due to vitiated Rakta accumulated in Dantaveshta (Gum) and gives rise to Raktasrava and Puyasrava   (Bloody and purulent discharge) from gums and loosening of teeth. Based on signs and symptoms described by allopathy science, the disease ‘Dantaveshta’ can be included under the broad heading of periodontitis.

One of the most noted complications of periodontal disease is tooth loss. Lacunae in modern treatment modalities are post operative pain, bleeding, root hypersensitivity, delayed  healing, taste changes etc.

In Ayurveda, local as well as systemic factors are also addressed, so recurrence can be reduced and other complications may also be prevented.

In Sushruta Samhita, Raktamokshana and Pratisarana has been described for the treatment of Dantaveshta. Acharya Yogratnakara mentioned the treatment of Dantaveshta similar to Raktapittahara. Rakta and Pitta are closely related entities, They tend to mutually contaminate each other. Chandanadi Kwatha is mentioned in the treatment of Raktapitta. Majority of drugs having the property of Pitta Shamaka and Rakta Prasadaka. So Chandanadi kwatha is selected here.

As per the scholar’s knowledge, no work has been carried out on Raktapittahara Chikitsa for DantaveshtatoaddressDushtashonita. Hence Considering the global and national burden of disease periodontitis, its grave complications and limitations in the allopathy science, this study has been taken for current research work.

Considering all these facts, this study has been planned to evaluate the efficacy of Prachchhana Karma and Lodhradi Pratisarana with and without adjuvant drug Chandanadi Kwatha orally in the treatment of Dantaveshta w.s.r. to periodontitis.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Patients having signs and symptoms of Dantaveshta.
  • Bleeding from gums (Raktasrava).
  • Pus discharge from gums (Puyasrava).
  • Halitosis (Daurgandhya).
  • Tooth Mobility (Chaladanta).
  • Discoloration of gums (Krishanata).
  • Pain (Vedana).
  • Gingival inflammation (Shotha).
  • Clinical Attachment loss (CAL) ≥ 3mm.
  • Probing Pocket Depth (PPD) ≥ 3mm.

排除标准

  • 1.Patient below 18 and above 60 years of age.
  • 2.Patient not willing for trial.
  • 3.Pregnant lady/ lactating mother.
  • 4.Severe dental complications like dental sinus, fractured tooth etc.
  • 5.Medical conditions like AIDS, Bleeding disorders, Cancer, Uncontrolled Diabetes on the basis of clinical history.
  • 6.Medications that affect disease condition like Chemotherapy, Radiotherapy, Steroids etc.
  • on the basis of clinical history.
  • 7.3rd degree of tooth Mobility.

结局指标

主要结局

To reduce the symptoms of dantaveshta.

时间窗: 30 days.

次要结局

  • To improve quality of life.(30 days.)

研究者

发起方
Government Akhandanand Ayurved College
申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Roshni F Patel

Government Akhandanand Ayurved College and Hospital

研究点 (1)

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