Practical Usability of EGFR Mutation Detection in ctDNA From Resectable NSCLC
- Conditions
- Lung Neoplasms
- Registration Number
- NCT04922073
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
The aim of the study is to assess the practical usability of EGFR mutation detection in ctDNA from early NSCLC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Patient with clinical stage IB to IIIA Non-small Cell Lung Cancer
- Patients with resectable lung cancer
- One of followings: 1) Never-smokers or ex-smokers who quit 10 years ago, 2) Female 3) Subsolid nodule in chest CT 4) Biopsy-proven adenocarcinoma
Exclusion Criteria
- Patients with metastatic lung cancer (Stage IIIB-IV)
- Patients who underwent chemotherapy or radiotherapy
- Patients with other malignancies
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Performance of the EGFR assay Immediately before the surgery ADPS EGFR Mutation Test using plasma sample from clinical stage IB-IIIA NSCLC patients (reference: EGFR assay in tissue specimen)
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does ctDNA EGFR mutation detection compare to tissue biopsy in resectable NSCLC for targeted therapy guidance?
What clinical outcomes are associated with ctDNA-based EGFR testing in early-stage NSCLC versus standard methods?
Which biomarkers in ctDNA predict response to EGFR tyrosine kinase inhibitors in resectable NSCLC patients?
What adverse events occur with EGFR inhibitor therapies in NSCLC patients identified via ctDNA mutation analysis?
How do ctDNA EGFR detection methods influence treatment strategies for resectable NSCLC compared to competitor liquid biopsy platforms?
Trial Locations
- Locations (1)
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center🇰🇷Seoul, Korea, Republic ofJunghee Kang, phDContactriverjh3.kang@gmail.com