Progressive post-resection program after pancreatic resection for malignoma and pre-cancerous lesions of the pancreas

Not Applicable

• Conditions: C25; Malignant neoplasm of pancreas

• Registration Number: DRKS00006786
• Lead Sponsor: Klinik für Allgemein- und ViszeralchirurgiePius-Hospital Oldenburg

Brief Summary

According to our data supervised exercise in pancreatic cancer patients and survivors may be proposed and started as soon as possible in order to improve certain aspects of QoL, since early controlled implementation seems to be safe. Also, benefits on some symptoms including physical and psychological aspects have been proved in this study. The impact on physical functioning is indeed so strong that even the small sample of this study was sufficient to demonstrate its significant effect. More data are needed to determine the optimal exercise frequency and intensity based on each patient´s training capacity or tumour stage, as a precision medicine approach is essential to address the issues of QoL. Well-designed multicentre randomized controlled trials with study populations between 20 and 1400 patients are required to examine the long-term effects of supervised and home-based exercise interventions on certain aspects of health related QoL after pancreatic cancer surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10-01
• Study Completion: 2019-11-28
• Results First Posted: 2021-09-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Patients with resectable pancreatic cancer, cancer of the distal biliary tract, neuroendocrine tumour, periampullary carcinoma, duodenal carcinoma, intraductal papillary mucinous neoplasia (IPMN)
- Age = 18 years
- Surgery and postoperative treatment in the Department of General- and Visceral Surgery, Pius-Hospital, Oldenburg, Germany

Exclusion Criteria

- Missing informed consent
- Physical inability to take part at the intensified physiotherapy program
- Analphabetism
- Inability of german language
- Physical/Mental disability to take part at the intensified physiotherapy program
- Surgery due to chronic (recurrent) pancreatitis or acute pancreatitis
- Insufficient compliance

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of life of the intervention group taking part in an intensified physiotherapy program 12 months after pancreatic resection assessed with the SF-8 and the EORTC QLQ-C30 and PAN26 questionnaires in the validated german translation.