Use of Neuromuscular Electrical Stimulation to Prevent Exercise Resistance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Fat oxidation
研究概览
简要总结
The study will find out if 100 minutes of electrical stimulation of muscle prevents the unfavorable consequence of insufficient exercise.
详细描述
Exercise resistance is characterized by the absence of exercise induced improvements in fat metabolism following a meal, and results from prolonged sedentary behavior between successive workouts (i.e. 2+ sedentary days between exercise bouts). The suggested energy expenditure threshold for avoiding exercise resistance is the equivalent of walking ~8,500 steps/day. However, population data indicate that the typical adult in the US only walks 5,000 steps/day (i.e. 3,500 steps below the threshold). Neuromuscular Electrical Stimulation (NMES) evokes skeletal muscle contractions and increases energy expenditure. The hypothesis to be explored in this current proposal is: NMES will prevent exercise resistance. The plan is to induce exercise resistance via short-term abstention from activity other than exercise, and then on a separate occasion, use NMES to prevent exercise resistance (i.e. the short-term abstention from exercise will be "replaced" with NMES).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Regularly active (more than 30 minutes of exercise per day, 3 days per week, over the previous 12 months)
- •Ability to complete at least one hour of treadmill exercise (i.e. jogging/running),
- •Willing to abstain from caffeine and alcohol for 24-hours prior to three different study visits
- •Competency in English
排除标准
- •Current or previous injuries that may hinder a participant's ability to exercise on a treadmill
- •A history of cardiopulmonary disorder that may be contra-indicative to treadmill exercise
- •Current use of cardio-pulmonary medication to treat a cardio-pulmonary condition
- •Currently breastfeeding
- •Pregnancy
研究组 & 干预措施
Demonstrating exercise resistance
Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. The next day, fat oxidation will be measured after eating a high-fat meal.
Trying to prevent exercise resistance
Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. They will receive 100 minutes of neuromuscular electrical stimulation. The next day, fat oxidation will be measured after eating a high-fat meal.
干预措施: neuromuscular electrical stimulation (Other)
结局指标
主要结局
Fat oxidation
时间窗: Blood will be sampled and triglyceride concentration measured. Study participants will eat a meal. Blood will be sampled and triglyceride concentration measured every 30-minutes for 4 hours.
Circulating triglyceride concentration after eating a high fat meal.
次要结局
未报告次要终点
研究者
Christopher Bell
Associate Prof
Colorado State University