NCT00000452已完成4 期
Naltrexone Treatment of Alcohol Dependence
National Institute on Alcohol Abuse and Alcoholism (NIAAA)2 个研究点 分布在 1 个国家目标入组 240 人开始时间: 1999年11月3日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 240
- 试验地点
- 2
研究概览
简要总结
The long-range goal of this ongoing research program is to find more effective treatments for alcohol dependence by combining medication with the appropriate psychosocial support. This proposal has three specific aims: (1) to compare the effectiveness of naltrexone (Revia) in three types of treatment settings; (2) to assess the effects of psychosocial support on medication compliance and treatment retention; and (3) to investigate the individual characteristics that may predict who is likely to benefit from additional psychosocial support versus simple medication management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets criteria for current diagnosis of alcohol dependence.
- •Subjects used more than 15 standard alcohol drinks (average)/week with at least 1 day of 5 or more drinks in the past 30 days.
- •Successful completion of medical detoxification.
- •Lives within a commutable distance to the Treatment Research Center and agrees to follow-up visits.
- •Understands and signs the informed consent.
排除标准
- •Current diagnosis of any substance dependence other than alcohol, nicotine, or marijuana.
- •Evidence of opiate use in the past 30 days.
- •Current treatment with psychotropic medications, including disulfiram (Antabuse) (excluding short-term use of benzodiazepines for detoxification).
- •History of unstable or serious medical illness, including need for opioid analgesics.
- •Severe physical or medical illnesses such as AIDS, active hepatitis, significant hepatocellular injury as evidenced by elevated bilirubin levels, and current severe psychiatric symptoms.
- •Use of an investigation medication in the past 30 days.
- •Female subjects who are pregnant, nursing, or not using reliable method of contraception.
研究者
研究点 (2)
Loading locations...
相似试验
已完成
4 期
Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)SchizophreniaBipolar DisorderSchizoaffective DisorderAlcohol DependenceNCT00453609State University of New York - Upstate Medical University15
终止
4 期
Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treatment: A Pilot TrialVeteransAlcohol DependenceNCT00461890State University of New York - Upstate Medical University20
已完成
4 期
Naltrexone Maintenance Treatment of AlcoholismAlcoholismNCT00000450The Scripps Research Institute159
已完成
4 期
Managing Alcoholism in People Who Do Not Respond to NaltrexoneAlcoholismNCT00115037University of Pennsylvania302
已完成
4 期
Pharmacogenetic Response to Naltrexone For Alcohol DependenceAlcohol DependenceNCT00831272David Oslin221