Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?

Not Applicable

• Conditions: Nervous System Diseases; Anaesthesia

• Registration Number: PACTR201810909649406

Brief Summary

intraoperative magnesium sulphate has a protective effect against developing postoperative cognitive dysfunction and reduce the serum level of S100B; the marker of neuronal degeneration

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-11
• Results First Posted: 2018-10-12
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1.Patients who are candidate for elective laparoscopic cholecystectomy
2.Patients should have the ability to read, write and do simple calculations
3.All the participants will be required to offer a written informed con¬sent

Exclusion Criteria

1.Patient subjected to gross hemodynamic or ventilatory fluctuations during the operation
2.Patient who developed postoperative shock or major bleeding
3.Patient with a history of neurodegenerative disease
4.Patients with concomitant medical or metabolic illness known to affect cognition
5.Patients with evidence of concomitant cerebrovascular stroke
6.Patient with a history of major head trauma
7. Patient with a history of epileptic fits in the last two years
8.Patient with a history of serious hearing or visual impairment
9.Patients with MRI brain showing structural lesion
10.Patients with a history of exposure to drug, toxic substances, alcohol, industrial agents, heavy metals, or any substance known to affect cognition.

Study & Design

• Study Type: Interventional
• Study Design: Not specified