The Influence of Different PEEP Values on Gas Exchange in Spontaneously Breathing Patients During Early Weaning
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 2
- 主要终点
- Changes in the Oxygen Partial Pressure and CO2 Partial Pressure in the arterial blood gas analysis
研究概览
简要总结
The purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.
详细描述
First, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. After 5 minutes an PaO2/FiO2 will be calculated and compared with a PaO2/FiO2 during ventilation with FiO2 - 30%.
The patients will be divided in two sections: Section A are the patients with less than 24 hours mechanical ventilation until weaning start. Section B are the patients with more than 24 hours until weaning start.
The patients in every section will be further divided in two groups. Group 1 will be weaned starting with a PEEP equal with P mean during BiPAP, Group 2 will be weaned starting with a PEEP equal with PEEP during BiPAP.
Further, the weaning will be conducted after an known algorithm. The differences in the oxygenation and decarboxylation will be measured after 30 and 120 Minutes for Group A and after 30, 120, 240, 360 Minutes for Group B.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All Patients that are mechanical ventilated on the intensive care unit.
排除标准
- •Patients under 18 years of age
- •Patients that where in an other study in the last 30 days
- •Patients that are enrolled in other studies
- •Pregnant woman
- •Nursing mothers
- •Existing severe Lung disease
- •Existing COPD Gold IV
结局指标
主要结局
Changes in the Oxygen Partial Pressure and CO2 Partial Pressure in the arterial blood gas analysis
时间窗: 30, 60, 90, 120, 360 Minutes
次要结局
未报告次要终点
研究者
Studienarzt K2A
P.D. dr. med. Martin Beiderlinden
Marienhospital Osnabrück