Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Acute Respiratory Distress Syndrome (ARDS)

Completed

• Conditions: ARDS: Acute Respiratory Distress Syndrome
• Interventions: Radiation: Chest computed tomography

• Registration Number: NCT01670747
• Lead Sponsor: Policlinico Hospital

Brief Summary

In this study gas-exchange and respiratory mechanics variations to PEEP change will be correlated to CT lung morphological modifications assessed at different airway pressures (5, 15, 30 and 45 cmH2O).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-08-14
• Study First Submitted QC: 2012-08-21
• Study First Posted: 2012-08-22
• Study Start: 2012-09
• Status Verified: 2015-03
• Primary Completion: 2015-03
• Study Completion: 2015-03
• Last Update Submitted: 2015-03-18
• Last Update Posted: 2015-03-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Clinical diagnosis of acute lung injury/ acute respiratory distress syndrome
• Mechanical ventilation

Exclusion Criteria

• Clinical diagnosis of chronic obstructive pulmonary disease
• Clinical diagnosis of pneumothorax
• Haemodynamic instability

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ARDS	Chest computed tomography	Sedated and mechanically ventilated patients admitted to ICU

Primary Outcome Measures

Name	Time	Method
Computer Tomography (CT) scan lung recruitment and CT lung weight	Study day (day 1)	Aim of the study is to determine the relationship between the opening pressures (recruitment) and closing pressures (PEEP) in order to prevent the opening and closing of the lung parenchyma

Trial Locations

Locations (1)

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; 🇮🇹 Milano, Italy