Inert Gas Rebreathing in Ventilated Patients

• Conditions: Respiratory Failure; Heart Failure; Sepsis; Renal Failure

• Registration Number: NCT01891253
• Lead Sponsor: Universitätsmedizin Mannheim

Brief Summary

Measuring hemodynamic parameters in ventilated patients is important yet still complicated to perform. Inert gas rebreathing (IGR) showed promising results when being compared to other invasive as well as non-invasive techniques for the measurement of cardiac output. The aim of our study is to evaluate the feasibility of IGR in ventilated patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-06-20
• Study First Submitted QC: 2013-07-02
• Study First Posted: 2013-07-03
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-24
• Last Update Posted: 2019-09-25
• Primary Completion: 2020-12
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• age 18 - 80 years
• mechanically ventilated patient
• existing PiCCO arterial line

Exclusion Criteria

• FiO2 > 60% (fraction of inspired oxygen)
• PEEP > 10 mmHg (positive end-expiratory pressure)
• SO2 < 90% (oxygen saturation )
• Systolic blood pressure < 90 mmHg
• Heart rate > 150 bpm
• APRV (airway pressure release ventilation)
• ICD (implantable cardioverter defibrillator) / pace maker
• [ Anaesthetic Conserving Device (Anaconda) ]

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cardiac output	1 day	Determination of cardiac output using invasive pulse contour analysis (PiCCO) and non-invasive inert gas rebreathing (Innocor)

Trial Locations

Locations (1)

Universitätsmedizin Mannheim; 🇩🇪 Manheim, Baden-Württemberg, Germany