Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars

Not Applicable

Completed

• Conditions: Tooth Extraction; Socket Preservation

• Registration Number: NCT06936358
• Lead Sponsor: Hams Hamed Abdelrahman

Brief Summary

Different materials and techniques are employed for socket preservation to reduce the alveolar bone resorption in both the horizontal and vertical dimensions as well as the soft tissue collapse after tooth extraction. Because of the repair abilities of the growth factors and proteins released by platelets, the development and application of platelet-enriched preparations have revolutionised the area of regenerative medicine.The present study will be designed to study the difference between A-PRF and IPRF with the addition of Xenograft in the preservation of bone in mandibular molars.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-22
• Primary Completion: 2024-12-17
• Study Completion: 2024-12-17
• Status Verified: 2025-04
• Study First Submitted: 2025-04-13
• Study First Submitted QC: 2025-04-13
• Last Update Submitted: 2025-04-13
• Study First Posted: 2025-04-20
• Last Update Posted: 2025-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Patients who need extraction of hopeless mandibular molars
• Teeth with advanced caries not amenable for conservative treatment
• Patients who are willing and fully capable of complying with the study protocol.

Exclusion Criteria

• Systemic diseases that prevent surgery
• Acute or chronic oral infections
• Periodontal diseases
• Heavy smokers or alcoholics
• On anticoagulant drugs.
• Pregnancy
• History of radiotherapy or chemotherapy of the head and neck region

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in healing	Baseline and 12 weeks	A modified Landry, Turnbull, and Howley healing index will be used to assess wound healing (HI). This entails evaluating the following parameters in a comparative manner using a dichotomic score (1/0). Tissue colour or the presence or absence of redness to indicate inflammatory processes; granulation tissue; suppuration; swelling; degree of tissue epithelialisation (partial or complete); and the presence or absence of bleeding and tenderness on palpation
change in bone density	Baseline and 12 weeks	Bone density will be measured using CBCT examinations

Trial Locations

Locations (1)

Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University; 🇪🇬 Alexandria, Egypt