Evaluation of Diaphragmatic Displacement During Spontaneous Breathing Trials in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Weaning success
研究概览
简要总结
Acute respiratory failure (ARF) is characterised by a discrepancy between load imposed on respiratory muscles and their capacity. Recently, diaphragmatic ultrasonography has been introduced in the clinical practice to evaluate diaphragmatic function. In particular, the investigators will focus on Diaphragmatic Displacement measured by M-mode ultrasonography. The aim of this study was to compare the diaphragmatic displacement with traditional weaning parameters in potentially ready to be extubated patients undergoing a spontaneous breathing trial (SBT).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •mechanically ventilated since more than 24 hours
- •clinical improvement of the underlying acute cause of the respiratory failure
- •adequate cough reflex
- •absence of excessive and/or purulent tracheobronchial secretion
- •stable cardiovascular status
- •stable metabolic status
- •adequate pulmonary function
- •adequate mentation
排除标准
- •age <18 years
- •pregnancy
- •presence of thoracostomy, pneumothorax or pneumomediastinum
- •presence of flail chest or rib fractures
- •neuromuscular disease
- •use of muscle-paralyzing agents within 48 hours before the study
- •history or new detection of paralysis or paradoxical movement of a single hemi-diaphragm on diaphragm ultrasonography
结局指标
主要结局
Weaning success
时间窗: within the first 48 hours after the spontaneous breathing trial
A successful weaning attempt was registered when patients were extubated and breathed spontaneously for more than 48 hours. The reinstitution of mechanical ventilation at the end of spontaneous breathing trial, reintubation within 48 hours or non-invasive ventilation (NIV) support after extubation defined a failed weaning attempt.
次要结局
未报告次要终点
研究者
Savino Spadaro
Dr
Università degli Studi di Ferrara