Relationship Between Blood Glucose Variability and Prognosis in Critically Ill Patients
- Conditions
- Diabetes
- Registration Number
- NCT03629704
- Brief Summary
This study is to evaluate the glycemic variation using Continuous Glucose Monitoring System in patients in the intensive care unit, find out the occult hypoglycemia, and investigate the relationship between glycemic variation, especially the incidence of hypoglycemia and prognosis of patients. Meanwhile, the inflammatory factors were measured and the relationship between inflammatory factors and glycemic variation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Patients with history of diabetes;
- Patients without history of diabetes, but their random blood glucose≧7.8mmol/L or fast blood glucose≧5 mmol/L;
- The patients hospitalized in care unit (ICU or CCU) for more than 48 hours.
Exclusion Criteria
- Patient had history of mental illness;
- Patient was not suitable for using the CGMS;
- blood glucose > 22.2 mmol/L at admission.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 28 day prognosis 0-28 days Case-fatality at 28 days
- Secondary Outcome Measures
Name Time Method Incidence of hypoglycemia 1-4 days Incidence of hypoglycemia
Acute Physiology and Chronic Health Evaluation II score 0-28 days Acute Physiology and Chronic Health Evaluation II score
Global registry of acute coronary events risk score 0-28 days Global registry of acute coronary events risk score
Twenty-four-hour mean blood glucose 1-4 days Twenty-four-hour mean blood glucose assessed by CGM
Mean amplitude of glycemic excursion every 24 h 1-4 days Mean amplitude of glycemic excursion every 24 h assessed by CGM