Effect of Yoga on Gut Microbiota Derived Metabolites in Type 2 Diabetes.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- 1. Trimethylamine N -oxide(TMAO), Choline, Betaine and Carnitine – by ELISA kit
研究概览
简要总结
The global incidence of type 2 diabetes mellitus (T2DM) is rising, and emerging research suggests that dysbiosis of the gut microbiota may play a significant role in the development of the disease. Metabolites produced by gut microbiota, such as short chain fatty acids, trimethylamine-N-oxide, tryptophan and indole derivatives, and bile acids and lipopolysacharides, have been implicated in the pathogenesis of T2DM. These metabolites are involved in crucial interactions between the host and microbiota, influencing disease mechanisms. (26) Therefore, there aren't many thorough research on the effects of yoga on gut microbiota in diabetes. Due to this gap in information, our research aims to address this issue by examining
the gut microbe derived metabolites changes before and after yoga practice.
The findings of this study will offer deeper insights into the connection between exercise and the
gut microbiome, potentially highlighting targets for interventions aimed at enhancing gut and metabolic health in patients with type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 40.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Age: 40-60 year with T2DM.
- •Diagnosed as Diabetic within 1 year (0-12month) HbA1c level more than 7% Participants willing to participate in the study.
排除标准
- •Pregnancy Participants with infections (acute and chronic), Recent surgeries Malignancy Renal disorders and other comorbidities Respiratory disorders Rheumatoid arthritis Diabetics already practicing yoga or regular physical activity, and seriously ill participants Not willing to participate in the study.
结局指标
主要结局
1. Trimethylamine N -oxide(TMAO), Choline, Betaine and Carnitine – by ELISA kit
时间窗: t0 - day 0 | t1 - 12th week
2. Blood sample is collected in blood bank around 8-10ml
时间窗: t0 - day 0 | t1 - 12th week
4. HbA1c
时间窗: t0 - day 0 | t1 - 12th week
3. Lipid profile
时间窗: t0 - day 0 | t1 - 12th week
次要结局
未报告次要终点
研究者
Shobha Vijay Kage
KAHER JN Medical College