A Comparative Study of Dexmedetomidine and Propofol As Sole Sedative Agent for Patients With End-Stage Renal Disease Undergoing Arteriovenous Fistula Surgery
Overview
- Phase
- Phase 4
- Intervention
- Propofol
- Conditions
- Arteriovenous Fistula
- Sponsor
- Baskent University
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- The incidence of adverse effects such as respiratory and hemodynamic events
- Last Updated
- 10 years ago
Overview
Brief Summary
The investigators designed a prospective randomized study to compare the conventionally used sedative drug propofol with a latest alternative dexmedetomidine (DEX), in patients with end-stage renal disease undergoing arteriovenous fistula (AVF) surgery.
Investigators
Ozlem Ozmete
Medical Doctor
Baskent University
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria were patients undergoing arteriovenous fistula (AVF) surgery aged between 20-70 with end stage renal failure on dialysis treatment.
Exclusion Criteria
- •Exclusion criteria were decompensated respiratory or heart failure, liver failure, obesity (body mass index\>30), severe obstructive sleep apnea, need for additional different drugs for sedation, chronic use of alcohol, opioids or other sedative drugs,mental disorders, cognitive disorders, language problems and history of allergy to any medications used in this study.
Arms & Interventions
Propofol
Propofol was administered at 1 mg/kg over a 10-min period followed by a continuous infusion at a rate of 1-1.5 mg/kg/h until the the begining of skin suture (n=24)
Intervention: Propofol
Dexmedetomidine (DEX)
DEX was administered at 1 μg/kg over a 10-min period followed by a continuous infusion at a rate of 1-1.5 μg/kg/h until the begining of skin suture (n=24)
Intervention: Dexmedetomidine
Outcomes
Primary Outcomes
The incidence of adverse effects such as respiratory and hemodynamic events
Time Frame: up to 24 hours postoperative
Secondary Outcomes
- The sedation onset time with using BIS and recovery times during the procedure.(up to 24 hours postoperative)