JPRN-UMIN000013343CompletedPhase 4
Assessment of suitable Antihypertensive therapies: Combination with high dose amlodipine/Irbesartan vs. triple combination with amlodipine/Irbesartan/Indapamide - ASAHI-AI study
Conditions
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Asahikawa Medical University
- Enrollment
- 94
Study Overview
Brief Summary
High-dose CCBs combined with ARBs and a triple combination with diuretics combined with standard-dose CCB/ARBs produced a similar efficacy in reducing the BP. Both combination therapies can be used safely and effectively in hypertensive patients uncontrolled by standard doses of ARBs and CCBs.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 20years-old to 85years-old (—)
- Sex
- All
Inclusion Criteria
- Not provided
Exclusion Criteria
- •1) Patients with secondary hypertension 2) Patients with a history of severe renal disease: serum creatinine>2.0 mg/dl 3) Patients with critical liver damage (AST or ALT>100 IU/l) 4) Patients with a history of adverse effects to ARBs 5) Bilateral renal artery stenosis 6) Patients with hyperkalemia >=5.5 mEq/L 7) Patients with pregnancy or breast-feeding 8) Patients with a poor prognosis such as a malignant tumor 9) Patients who are considered not to be eligible for the study by the investigator due to medical reasons
Investigators
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