Intracranial Stimulation Mapping In Epilepsy
Not Applicable
Recruiting
- Conditions
- Epilepsy
- Registration Number
- NCT05290610
- Lead Sponsor
- University of Minnesota
- Brief Summary
This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Male or female 18 years and older at screening.
- Written informed consent is obtained from the participant to comply with the requirements of the study.
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Currently undergoing clinically indicated intracranial EEG monitoring for planning of epilepsy surgery in the University of Minnesota/MINCEP program.
Exclusion Criteria
- Pregnancy ruled out prior to approval for intracranial EG monitoring.
- Persons who are rendered temporarily or permanently invulnerable by inability to understand the research due to study complexity, cognitive impairment, or by inability to make independent decisions owing to University of Minnesota or to Fairview health services.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method The effect of prefrontal direct electrical brain stimulation on cognitive effort Immediately after stimulation sessions The change in subjective value of cognitive effort (area under the curve) after direct electrical brain stimulation to different areas of the prefrontal cortex during an effortful task
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie cerebral function localization via intracranial stimulation in partial epilepsy patients?
How does intracranial stimulation mapping compare to standard-of-care methods like fMRI in predicting seizure outcomes for epilepsy surgery?
Which biomarkers are associated with inter-regional information flow in epilepsy as identified by the InStim Study's functional mapping?
What adverse events are reported in intracranial stimulation mapping procedures for epilepsy and how are they mitigated?
How might data from the InStim Study's brain mapping influence the development of neuromodulation therapies or antiepileptic drugs?
Trial Locations
- Locations (1)
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
University of Minnesota🇺🇸Minneapolis, Minnesota, United StatesAlexander Herman, MD, PhDContact612-625-1194herma686@umn.edu