se of intravenous acetylsalicylic acid (‘Aspirin’) as a novel antidote for human paraquat poisoning- can it reduce the 70% mortality rate and oxidative stress?
Phase 2
- Conditions
- Paraquat self poisoning
- Registration Number
- SLCTR/2009/001
- Lead Sponsor
- Welcome Trust and NHMRC through SACTRC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow up complete
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Paraquat self poisoning presenting within 24 hours and a positive urine dithionite test
Exclusion Criteria
Age under 14 years pregnanacy presenting after 24 hours known aspirin allergy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measure of oxidative markers as outlined before 3. Plasma and EBC 4-Hydroxy-2-nonenal and F2?-isoprostane concentrations (GC/MS) 4. Plasma and EBC proteins CC16 and SP-D (Assay kits) 5. EBC Hydrogen peroxide concentrations (Assay kit) 6. EBC Thiobarbituric Acid Reactive Substances (TBARS) (spectrophotometric assay) 7. EBC Proteomic 8. Urinary F2?-isoprostane and prostacyclin levels<br> []<br>
- Secondary Outcome Measures
Name Time Method Death []<br>