Parkinson's Repository of Biosamples and Network Datasets (Tracking Parkinson's)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson's Disease
- Sponsor
- South Glasgow University Hospitals NHS Trust
- Enrollment
- 2614
- Primary Endpoint
- Proportion of participants with Parkinson's who have gene mutations and variations
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Prospective observational study of Parkinson's disease with repeat clinical assessment and biobanking of blood samples.
Detailed Description
To identify genetic and biomarker factors which affect the expression of Parkinson's Disease. Primary objective: To define the severity and rates of progression of clinical features of Parkinson's Disease. Secondary objective: To relate clinical phenomenology of Parkinson's disease to genetic and biomarker changes.
Investigators
Dr Donald Grosset
Senior Research Fellow
University of Glasgow
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Proportion of participants with Parkinson's who have gene mutations and variations
Time Frame: Up to 36 months
Genotyping for leucine rich repeat kinase 2 (LRRK2), Glucocerebrosidase (GBA) (all cases) and Parkin, Phosphatase and tensin homolog-induced putative kinase 1 (PINK1)(onset\<50years)
Secondary Outcomes
- Categorisation of subtypes of Parkinson's using cluster analysis(At 4 years)
- Proportion of cases with Parkinson's who have vascular comorbidity and risk factors(At 4 years)