Explorative study on the impact of tea ingestion on forearm resistance artery endothelial functio

Completed

• Conditions: diseas of the heart and vessels; 10082206

• Registration Number: NL-OMON40898
• Lead Sponsor: nilever

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2015-08-31
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 22

Inclusion Criteria

- Males and post-menopausal (> 1 years) females
- Aged >45 and < 75 years
- Body mass index (BMI) of *18.0 and *35.0 kg/m2

Exclusion Criteria

- Regular performance of strenuous exercise/sport of > 2 hours per week
- Current smoker or has stopped smoking less than 6 months before start of study
- Self reported alcohol intake of >21 units/week)
- Established cardiovascular disease
- Diabetes mellitus
- Blood pressure > 160/100 mmHg
- Subjects taking any medication that might affect endothelial function (e.g. but not limited to beta-blockers, ACE-inhibitors, statins, anti-coagulants, anti-depressants, hormone replacement therapy) will be excluded from the study. Subjects who are on stable medication for which there is no indication of an effect on endothelial function, will be allowed to participate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Forearm resistance artery blood flow (measured using venous occlusion<br /><br>plethysmography) in response to incremental doses of acetylcholine<br /><br>(endothelium-dependent dilator; primary parameter), sodium nitroprusside<br /><br>(endothelium-independent dilator; secondary parameter) and L-NMMA (nitric oxide<br /><br>synthase blocker; secondary parameter). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Blood pressure</p><br>