Influence of Adiponutrin in Chronic Liver Disease

Completed

• Conditions: Alcoholic Liver Disease

• Registration Number: NCT01122797
• Lead Sponsor: Erasme University Hospital

Brief Summary

Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2002-12
• Study Start: 2003-01
• Primary Completion: 2010-01
• Study Completion: 2010-03
• Study First Submitted: 2010-05-11
• Study First Submitted QC: 2010-05-11
• Last Update Submitted: 2010-05-11
• Study First Posted: 2010-05-13
• Last Update Posted: 2010-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 658

Inclusion Criteria

• Excess alcohol intake
• Abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or a suspicion of cirrhosis related to ALD
• Caucasian ethnicity

Exclusion Criteria

• Presence of any other chronic liver disease
• Co-infection with human immunodeficiency virus

Controls:

Inclusion Criteria:

• Caucasian ethnicity

Exclusion Criteria:

• Presence of a disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.		After liver histology assessment for liver liver dammage a potential correlation of fibrosis and steatosis was studied with rs738409 PNPLA3 polymorphism

Trial Locations

Locations (1)

Hopital Erasme- Dpt of Gastroenterology; 🇧🇪 Brussels, Belgium