Evaluation of the influence of metabolic and genetic factors on energy regulation in stomach reduction surgery

Not Applicable

• Conditions: Women; obesity; M01.975

• Registration Number: RBR-8k5jsj
• Lead Sponsor: Instituto de Biociências de Botucatu - UNESP

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-12-21
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

Being female; Age between 20 and 45 years in menacme; Body Mass Index greater than 40 kg / m2 and less than 60 kg / m2; Waiting in the queue to perform the surgical procedure; Do not present diseases that cause changes in energy metabolism such as diabetes mellitus, hypothyroidism, HIV infection, neoplasms, heart diseases, nephropathies and liver diseases; Do not present diseases that cause edema such as venous insufficiency, pregnancy, thrombosis, sepsis, inflammation, lymphedema; Do not use medicines that cause metabolic and absorptive changes such as diuretics, amphetamines, thyroid hormones, topiramate, orlistat, corticosteroids, etc.

Exclusion Criteria

We excluded women who did not present optimal health conditions for the surgical procedure (diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies) after conducting the admission tests for the research and patients living outside the DRS-10 region (near the collection site).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expected outcome 1: it is expected to verify if there is influence of bariatric surgery in the alterations of the total energy expenditure measured by the doubly-labeled water technique. This verification was evaluated based on the significant difference (p <0.05) in the energy expenditure measured at 6 and 12 months of surgery in relation to the preoperative period.;Outcome Found 1: It was verified that after the surgical procedure the total energy expenditure of the patients presented a reduction of 20% (p <0.05) at 6 months of surgery and 10% (p <0.05) at 12 months of surgery, when compared to values of total energy expenditure measured at the preoperative time. This result indicates the presence of energetic hypometabolism after the surgical procedure to treat obesity.