Randomised Study of the Effect of Exercise Training on Patients in Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- cardiac output
研究概览
简要总结
PURPOSE Physical exercise is beneficial for patients with ischemic heart disease and chronic heart failure, while little is known about the effect in atrial fibrillation (AF). The investigators studied the effect of physical exercise on cardiac output (CO), max. exercise capacity, biomarkers and quality of life (Qol) in patients with AF in a randomised study of physical exercise training three times weekly for twelve weeks.
HYPOTHESIS Exercise training improves cardiac output (CO), max. exercise capacity, biomarkers and quality of life (Qol) in patients with AF.
METHODS Assessment of exercise capacity, CO, Qol, body composition, six minute walk test and muscular strength was performed before and after 12 weeks.
Resting echocardiography was done at baseline. CO was measured using impedance cardiography at rest and during maximal exercise testing on an ergometer bicycle. Body composition, muscular strength and six minutes walking capacity were measured before and after the training period. Qol was evaluated by the use of the standardized validated questionnaires Short Form 36 (SF-36) and the Minnesota Living with Heart Failure Questionnaire (MLHF-Q).
Training consisted of aerobic exercise at 70 percent of max. capacity estimated by Borg-scale.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult subjects in permanent atrial fibrillation, willing to participate in a 12 weeks training program and able to give informed consent to participation were eligible for the study.
排除标准
- •Subjects with severe refractory hypertension
- •previous heart valve surgery, moderate to severe COPD
- •restrictive lung disease, moderate to severe asthma
- •pregnant or lactating subjects
- •patients with a very low life expectancy
- •patients who were unable to exercise or comply with the study protocol
结局指标
主要结局
cardiac output
时间窗: participants will be followed for the duration of the intervention, an average of 12 weeks
participants will be followed for the duration of the intervention, an average of 12 weeks
exercise capacity
时间窗: participants will be followed for the duration of the intervention, an average of 12 weeks
participants will be followed for the duration of the intervention, an average of 12 weeks
Quality of life
时间窗: participants will be followed for the duration of the intervention, an average of 12 weeks
participants will be followed for the duration of the intervention, an average of 12 weeks
次要结局
- muscle strength(participants will be followed for the duration of the intervention, an average of 12 weeks)
- biomarkers ANB, BNP(participants will be followed for the duration of the intervention, an average of 12 weeks)
- Body composition DEXA-scan(participants will be followed for the duration of the intervention, an average of 12 weeks)