Occurrence of venous thromboembolism after thoracic surgery in patients receiving thrombosis prophylaxis with 40mg enoxaparin.Study 1: Occurrence of venous thrombus embolism after anatomical lung resection in patients with lung cancer
- Conditions
- I26I80C34Pulmonary embolismPhlebitis and thrombophlebitisMalignant neoplasm of bronchus and lung
- Registration Number
- DRKS00020525
- Lead Sponsor
- ungenklinik,Kliniken der Stadt Köln gGmbH, Uniklinik der Privaten Universität Witten/Herdecke
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 108
Inclusion Criteria
Age = 40 years
- Indication for anatomical lung resection
- Detected or suspected lung carcinoma
- Information and signed consent
- The use of antiplatelet drugs (e.g. ASS, Clopidogrel) is permitted
Exclusion Criteria
- VTE in medical history within the last 12 months
- severe coagulation disorder (PTT > 40s, Quick < 60%, INR > 1.5, thrombocytes < 50000/µl)
- Renal insufficiency (creatinine > 1.15 mg/dl for men and 0.95 mg/dl for women)
- Known coagulopathy
- Existing drug anticoagulation
- Contrast agent allergy
- Hyperthyroidism
- Pregnancy and lactation
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of patients with adequate prophylactic anti factor Xa level (0.3 - 0.5 U/ml) on the 3rd postoperative day reciving VTE prophylaxis with 40mg enoxaparin
- Secondary Outcome Measures
Name Time Method - Rate of postoperative deep vein thrombosis<br>- Rate of postoperative pulmonary embolisms<br>- Rate of postoperative venous thrombembolisms<br>- Influence of anti-factor Xa level on the incidence of venous thrombembolism<br>- Influence of patient characteristics (BMI, gender, renal function) on antifactor Xa activity and incidence of venous thrombembolism<br>- Postoperative complications, especially intra- and postoperative bleeding