Effect of Combined Inspiratory Muscle Training and Continuous Positive Airway Pressure in Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary Rehabilitation
- Sponsor
- Zhujiang Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Respiratory muscle strength(composite outcome measure)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Inspiratory muscle training(IMT) was one of the widely used pulmonary rehabilitation method in COPD patients.However, when the respiratory muscles are fatigue without sufficient rest, IMT may increase muscle fatigue and aggravate muscle damage. Noninvasive positive pressure ventilation (NPPV) is another important strategy of pulmonary rehabilitation which could overcome airway resistance and reduce respiratory work, improve respiratory muscle fatigue. Therefore, the purpose of this study was to explore the effective of the "IMT - NPPV sequential" rehabilitation method, that is, first inspiratory muscle training, followed by respiratory muscle resting (non-invasive positive pressure ventilation).
Detailed Description
Exploring the effects of the new rehabilitation method of "IMT - NPPV sequential", comparing with the single rehabilitation strategy such as inspiratory muscle training and non-invasive positive pressure ventilation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with pulmonary function test of forced expiratory volume at one second (FEV1)/forced vital capacity(FVC) \< 70% after inhalation of bronchial dilation agent. Patients in a clinically stable state.
Exclusion Criteria
- •Patients were excluded if they had other respiratory diseases ,or evidence of pneumothorax or mediastinal emphysema and pacemaker installed.
- •Patients with acute cardiovascular event and severe cor pulmonale. Patients with poor compliance. An Other causes of diaphragmatic dysfunction
Outcomes
Primary Outcomes
Respiratory muscle strength(composite outcome measure)
Time Frame: Change from baseline to 8 weeks
Currently, the maximal inspiratory pressure (PImax) and maximal expiratory pressures(PEmax) are measured by a digital manometer (AZ-8205, AZ Instrument, Taichung City, Taiwan)and combined to evaluate respiratory muscle function.
Secondary Outcomes
- Exercise capacity(Change from baseline to 8 weeks)
- Pulmonary function(composite outcome measure)(Change from baseline to 8 weeks)
- Symptom Evaluation(composite outcome measure)(Change from baseline to 8 weeks)
- Diaphragmatic function(Change from baseline to 8 weeks)